An experiment was conducted to test the hypothesis that replacing soybean meal (SBM) with a hydrothermal mechanical processed (HTM) SBM (ProvisoyTM), optimized for digestibility, would improve growth performance of nursery pigs. In total, 1,680 weaned pigs [5.4 ± 0.2 kg body weight (BW)] were allotted to 16 replicate pens per treatment (21 pigs per pen) in 2 barns. Pens were blocked by location within barn and randomly allotted to 5 treatments with 0, 5, 10, 15, and 20% HTM SBM. A low complexity diet with 31% conventional SBM and limited inclusion of highly digestible protein ingredients and health promoting additives was used as the basal diet for the 0% HTM SBM treatment, and HTM SBM was added at the expense of conventional SBM at levels of 5, 10, 15, and 20% in phase 1 (d 0-10) and phase 2 (d 10-22), respectively. Pig and feed weights were recorded at the beginning and end of each phase. Data were analyzed using the lme4 package of R 4.1.2, and the statistical model included the fixed effect of treatment, as well as the random effects of barn and location within barn. Mortality and removals were analyzed as generalized linear mixed models, with a binomial distribution. Contrasts were used to evaluate the linear and quadratic effect of increased dietary inclusion of HTM SBM. Results indicated that increasing HTM SBM linearly improved (P < 0.01) gain:feed (G:F) in phase 1 and tended (P < 0.10) to linearly improve average daily gain (ADG) and G:F day 0 to 22 post-weaning. Mortality and removals were numerically reduced when HTM SBM was added in the diet.