The objective of this study was to deliver a set of statistically significant regression equations (RE) for lysine (LYS) & arginine (ARG) that will allow poultry nutritionists & formulators to estimate the amino acid digestibility (AAD) of these amino acids (AAs) using a newly standardized protocol for the KOH protein solubility (KOHPS) test applied to commercial lots of soybean meal (CSBM). A total of 88 samples from a set of 100 previously analyzed for in vivo AAD and kept in frozen storage were analyzed for KOHPS. KOHPS values ranged from 86% to 13% while digestible LYS (DLYS) coefficients (COEFF) ranged from 0.96 to 0.47. Digestible ARG (DARG) COEFF ranged from 0.97 to 0.62. Because it became evident from the total LYS & total ARG analyses of the original samples that a net destruction of LYS & ARG occurred as KOHPS dropped. Therefore, previously published RE for total AAs regressed on protein content were used to calculate destruction-corrected LYS & ARG contents. Regressions of digestible COEFF on KOHPS were then run with & without corrected digestible COEFF for both AAs. Linear regression provided the best fit for KOHPS vs. corrected digestible COEFF for both LYS & ARG. One-slope broken line regression for LYS indicated that convergence criterion was met at KOHPS=80% & DLYS coefficient=0.88 meaning that an adequately processed CSBM lot by solvent extraction is optimum at a minimum of 80% KOHPS which in turn is correlated with a minimum in vivo DLYS of 0.88. Having a statistically significant RE between KOHPS & DLYS COEFF for CSBM contributes to the realization of precision nutrition. The data confirmed a long time observation that ARG is more digestible than LYS in CSBM, therefore by setting the minimum of 80% KOHPS for CSBM without Maillard reaction damage (overprocessing) on the basis of DLYS both AAs are at high AAD provided trypsin inhibitors are not in excess (underprocessing).