Most broiler nutrient requirement suggestions are given to maximize growth rate and minimize feed conversion ratio (FCR). Economic return and profit analysis are often neglected. In a previous study, we found that 20% amino acid (AA) reduction increased FCR in all 5 commercial broilers tested, but the cost of feed required to correspondingly increase BW was decreased in 4 out of the 5 strains. In the current study, a randomized complete block design with a factorial arrangement of 12 treatments (3 ME × 4 AA) was used. The 3 ME levels were 100, 92, and 84% of the commercially recommended level. The 4 levels of digestible AA (lysine, TSAA, and threonine) were 100, 90, 80, and 70% of the recommended level. A total of 864 Ross × Ross 708 broilers were randomly allocated to 6 blocks. Each block contained 12 pens with 12 birds per pen. Data were analyzed using a two-way ANOVA. Significance level was set at P < 0.05. Mortality was not affected by any treatments (P > 0.05). The combination of lowest dietary AA level (70%) and highest ME level (100%) resulted in the lowest BW from d 10 (P = 0.003) and through the remainder of the study period, including d 24, 34, 41, 48, and 55 (P = 0.007, 0.009, 0.006, 0.0004, and 0.002, respectively). Birds fed 70% AA exhibited higher FCR from d 10 to 24, as compared to birds fed 80, 90, and 100% dietary AA (P < 0.0001); however, the 70% of AA decreased FCR from d 48 to 55, as compared to 90 and 100% AA (P = 0.024). The lowest ME level (84%) increased FCR from d 41 to 48 (P = 0.015). Due to the lower cost of feed with lower AA and ME, the economic return to produce the same amount of BW on d 41 was increased by feeding the birds 70 and 80% AA as compared to 100% AA (P = 0.007); similarly, the economic return on d 55 was increased by feeding the birds 70 and 80% AA as compared to 90 and 100% AA (P < 0.0001). The economic return was also increased by feeding the birds 84 and 92% ME as compared to 100% ME on both d 41 and 55 (P < 0.0001).